冯雪竹，细胞分子生物学博士，研究员，博士生导师。安徽省干细胞协会理事，中国解剖学会组织胚胎学分会常务委员。

毕业于美国威斯康星大学麦迪逊分校，师从干细胞研究领域的先驱James A Thomson教授。实验室长期从事生殖细胞发育、环境应激和寿命调控信号通路的前沿研究。相关研究成果以第一作者或通讯作者发表于Nature Structural & Molecular Biology（x2）、Nature Communications (x3)、PNAS(x2)、Cell Reports , Nucleic Acids Research, Developmental Cell 等SCI高影响力期刊,共20余篇；主持国家自然科学基金面上项目3项，参与国家重点研发项目1项。迄今为止共同指导博士生11人，硕士生2人。毕业学生大部分继续在国内外从事博士后研究或已担任教授职务。

教育经历

    1994 - 1999   北京医科大学 (现北京大学医学部)，临床医学，学士

    1999 - 2001   北京医科大学 (现北京大学医学部)， 组织胚胎学系，助教 

     2001- 2007   威斯康星大学麦迪逊分校（University of Wisconsin-Madison），细胞分子生物学，博士

     科研与学术工作经历

     2008 - 2014   美国威斯康星州细胞动力有限公司（Cellular Dynamics International Inc.，Madison,WI），高级研究员

     2014 - 2019   中国科学技术大学生命科学学院， 特任副研究员

     2019 - 2023   中国科学技术大学生命科学与医学部，特任研究员

     2023 - 至今    世预赛免费直播入口基础医学院，研究员，校聘教授

1. 国家自然科学基金面上项目。课题名称:“秀丽线虫中H3K9二甲基化调控寿命机制的研究”。项目起止年月：2025.01- 2028.12。

2. 国家自然科学基金面上项目。课题名称：“衰老过程中反义核糖体小干扰RNA的功能与机制”。项目起止年月：2021.01-2024.12。

3. 国家重点研发计划“发育编程及其代谢调节”专项，课题名称："环境应激和营养失衡所致获得性性状及其代际传递机制”。起止年月：2019.09-2024.08。

4. 国家自然科学基金面上项目。课题名称：“细胞质RNA干扰介导的多代遗传的机制研究”。项目起止年月：2019.01-2022.12。

5. 国家自然科学基金青年项目。课题名称：“CRISPR/Cas9介导的染色体转位与剂量补偿效应研究”。起止年月：2016.01-2018.12。

6. 安徽省自然科学基金项目。课题名称：“秀丽线虫中CRISPR介导的染色体易位的研究”。项目编号：1608085MC50。起止年月：2016.07-2018.6。

1. Chengming Zhu(#), Xiaoyue Si(#), Xinhao Hou, Panpan Xu, Jianing Gao, Yao Tang, Chenchun Weng, Mingjing Xu, Qi Yan, Qile Jin, Jiewei Cheng, Ke Ruan, Ying Zhou, Ge Shan, Demin Xu, Xiangyang Chen, Shengqi Xiang(*), Xinya Huang(*), Xuezhu Feng(*) & Shouhong Guang(*) (2025) piRNA gene density and SUMOylation organize piRNA tranional condensate formation. Nature Structural & Molecular Biology 2025 (accepted) (Nature Index,中科院一区）

2. Qile Jin(#), Xuezhu Feng(#), Minjie Hong, Ke Wang, Xiangyang Chen, Jiewei Cheng, Yan Kuang, Xiaoyue Si, Mingjing Xu, Xinya Huang(*), Shouhong Guang(*) and Chengming Zhu(*) (2025a) Peri-centrosomal localization of small interfering RNAs in C. elegans. SCIENCE CHINA Life Sciences 2025 Jan 14, https://doi.org/10.1007/s11427-024-2818-7

3. Xiaona Huang(#), Xuezhu Feng(#), Yong-hong Yan(#), Demin Xu, Ke Wang, Chengming Zhu, Meng-qiu Dong, Xinya Huang(*), Shouhong Guang(*) and Xiangyang Chen(*) (2024) Compartmentalized localization of perinuclear proteins within the germ granuosome in C. elegans. Developmental Cell 2024 Dec 31(Nature Index,中科院一区）

4. Minjie Hong(#), Xiaotian Zhou(#), Chenming Zeng, Demin Xu, Ting Xu, Shimiao Liao, Ke Wang, Chengming Zhu, Ge Shan, Xinya Huang(*), Xiangyang Chen(*), Xuezhu Feng(*) & Shouhong Guang(*)  Nucleolar stress induces nucleolar stress body formation via the NOSR-1/NUMR-1 axis in Caenorhabditis elegans. Nature Communications, 2024 volume 15 (Nature Index,中科院一区）

5. Xiangyang Chen(#), Ke Wang(#), Farees Ud Din Mufti(#), Demin Xu, Chengming Zhu, Xinya Huang, Chenming Zeng, Qile Jin, Xiaona Huang, Yong-hong Yan, Meng-qiu Dong, Xuezhu Feng(*), Yunyu Shi(*), Scott Kennedy(*) & Shouhong Guang(*) Germ granule compartments coordinate specialized small RNA production. Nature Communications, 2024 Jul 10;15(1):5799. doi: 10.1038/s41467-024-50027-3 (Nature Index,中科院一区）

6. Demin Xu(#), Xiangyang Chen(#), Yan Kuang, Minjie Hong, Ting Xu, Ke Wang, Xinya Huang, Chuanhai Fu, Ke Ruan, Chengming Zhu(*), Xuezhu Feng(*) and Shouhong Guang(*) (2023) rRNA intermediates coordinate the formation of nucleolar vacuoles in C. elegans. Cell Reports, 2023 Aug 29;42(8):112915. doi: 10.1016/j.celrep.2023.112915. Epub 2023 Aug 1(中科院一区）

7. Xinhao Hou(#), Mingjing Xu(#), Chengming Zhu(#), Jianing Gao, Meili Li, Xiangyang Chen, Cheng Sun, Björn Nashan, Jianye Zang, Shouhong Guang(*), and Xuezhu Feng(*) (2022) Systematic characterization of chromodomain proteins reveals an H3K9me1/2 reader regulating aging in C. elegans. Nature Communications, 2023 Mar 6;14(1):1254. doi: 10.1038/s41467-023-36898-y (Nature Index,中科院一区)

8. Ting Xu, Shimiao Liao, Meng Huang, Chengming Zhu, Xiaona Huang, Qile Jin, Demin Xu, Chuanhai Fu, Xiangyang Chen(*), Xuezhu Feng(*) and Shouhong Guang(*) (2023) A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans. PLoS Genetics, 2023 Feb 10;19(2):e1010628. doi: 10.1371/journal.pgen.1010628

9. Meng Huang, Minjie Hong, Chengming Zhu, Di Chen(*), Xiangyang Chen(*), Shouhong Guang(*), and Xuezhu Feng(*) (2022) H3K9me1/2 methylation limits the lifespan of C. elegans. eLife 2022; 20;11:e74812. doi: 10.7554/eLife.74812 (Nature Index)

10. Xinhao Hou(#), Chengming Zhu , Mingjing Xu , Xiangyang Chen , Cheng Sun , Björn Nashan(*), Shouhong Guang(*) , Xuezhu Feng(*) (2022) The SNAPc complex mediates starvation-induced trans-splicing in Caenorhabditis elegans  Journal of Genetics and Genomics 2022 Mar S1673-8527(22)00076-5 2022.03

11. Shimiao Liao(#), Xiangyang Chen(#), Ting Xu(#), Qile Jin, Zongxiu Xu, Demin Xu, Xufei Zhou, Chengming Zhu(*), Shouhong Guang(*) and Xuezhu Feng(*) (2021) Antisense ribosomal siRNAs inhibit RNA polymerase I-directed tranion in C. elegans Nucleic Acids Research 2021 Sep 20;49(16):9194-9210 (中科院一区）

12. Xinya Huang(#), Peng Cheng(#), Chenchun Weng, Zongxiu Xu, Chenming Zeng, Xiangyang Chen(*), Chengming Zhu(*), Shouhong Guang(*), and Xuezhu Feng(*) (2021) A chromodomain protein mediates heterochromatin-directed piRNA expression. PNAS, 2021 Jul 6;118(27):e2103723118. doi: 10.1073/pnas.2103723118 (Nature Index,中科院一区)

13. Xiaoyang Wang(#), Chenming Zeng(#), Shanhui Liao(#), Zhongliang Zhu, Jiahai Zhang, Xiaoming Tu, Xuebiao Yao, Xuezhu Feng(*), Shouhong Guang(*), and Chao Xu(*) (2021) Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nature Communications, 2021 Sep 22;12(1):5595. doi: 10.1038/s41467-021-25896-7 (Nature Index,中科院一区)

14. Chenming Zeng (#), Chenchun Weng (#), Xiaoyang Wang (#), Yong-Hong Yan (#), Wen-Jun Li, Demin Xu, Minjie Hong, Shanhui Liao, Meng-Qiu Dong, Xuezhu Feng (*), Chao Xu (*), and Shouhong Guang (*) (2019) Functional proteomics identifies a PICS complex required for piRNA maturation and chromosome segregation. Cell Reports 2019 Jun 18;27(12):3561-3572.e3. doi: 10.1016/j.celrep.2019.05.076 (中科院一区）

15. Fei Xu (#), Xuezhu Feng (#), Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, and Shouhong Guang (*)（2018）A cytoplasmic Argonaute protein promotes the inheritance of RNAi. Cell Reports. 2018 May 22;23(8):2482-2494. doi: 10.1016/j.celrep.2018.04.072 (中科院一区）

16. Chengming Zhu (#), Qi Yan (#), Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng (*), Shouhong Guang (*) (2018) Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. PNAS 2018 Oct 2;115(40):10082-10087. doi: 10.1073/pnas.1800974115 (Nature Index,中科院一区)

17. Xufei Zhou (#), Xuezhu Feng (#), Hui Mao, Mu Li, Fei Xu, Kai Hu, and Shouhong Guang(*) (2017) RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway. Nature Structural & Molecular Biology 2017 Mar;24(3):258-269. doi: 10.1038/nsmb.3376 (Nature Index,中科院一区）

18. Chen X (#), Li M (#), Feng X (*), Shouhong Guang (*) (2015) Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans. Genetics 2015 Dec;201(4):1295-306 doi: 10.1534/genetics.115.181883.

19. Hui Mao (#), Chengming Zhu (#), Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng (*), and Shouhong Guang (*) (2015) The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans. Current Biology 2015 Sep 21;25(18):2398-403. doi: 10.1016/j.cub.2015.07.051. Epub 2015 Sep 10.

参与编写的论著：

“十四五”本科高等教育规划教材 《组织学与胚胎学》 北京大学医学出版社第5版 编委