汤继辉，教授

研究方向：药物新剂型与新制剂、新型给药系统的研究

电子邮箱：tangjh@ahmu.edu.cn

办公室：知行楼B1213

教育经历：

(1) 2009/09-2012/06， 中国药科大学，药学院，博士

(2)2003/09-2006/06，安徽中医药大学，药学院，硕士

(3)1999/09-2003/06，安徽中医药大学，药学院，学士

工作经历：

(1)2022/12至 今，世预赛免费直播入口，药学院，教授

(2) 2016/09- 2022/12，世预赛免费直播入口，药学院，副教授

(3)2013/09-2016/02,世预赛免费直播入口,博士后

(4) 2009/07-2016/08，世预赛免费直播入口，药学院，讲师

(5) 2006/06-2009/06， 世预赛免费直播入口，药学院， 助教

学术荣誉：安徽省学科（专业）带头人培育人选

学术兼职：2020/03，《现代药物靶点（Current Drug Targets）》的客座编辑

科研项目：

1.安徽省自然科学基金面上项目：基于“Dont eat me”信号构建的免疫逃逸纳米制剂提高肿瘤光动力治疗效果及其机制研究（2308085MH308），2023.9-2026.8，10万元，在研主持

2.安徽省药品监管科学研究重点项目：基于药物吸收建立的新型溶出方法及其用于药物质量监测的研究（AHYJ-KJ-202206），2023.1-2024.12，10万元，结题，主持

3.安徽高校自然科学研究项目：基于磷脂酰丝氨酸特异性识别肽及pH敏感双靶向制剂的研究（KJ2020A0157），2021.01-2023.12，6万元，结题，主持

4.新安医学教育部重点实验室开放基金：中药桔梗对荆芥载药上浮作用物质基础及机制研究（2020xayx02），2021.01-2023.12，6万元，结题，主持

5.国家自然科学基金青年基金：针对肿瘤细胞周期的时相靶向制剂的研究（81503004），2016.01-2018.12，17.9万元，结题，主持

6.安徽省自然科学基金青年项目：基于叶酸修饰聚合物胶束的细胞周期特异性靶向给药系统的研究（1408085QH189），2014/07-2016/06，7万元，结题，主持

7.安徽省高校省级优秀人才基金重点项目：叶酸修饰聚氨基酸胶束主动靶向给药系统的研究（2013SQRL019ZD），2014/01-2016/12，9万元，结题，主持

发表论文情况：

1.Lele Wang, Tijie Duan, Yawen Gao,Heqing Liu, Rui Sun,Tong Wu, Jihui Tang*. Development and in vitro-in vivo evaluation of a novel sustained-release tablet based on constant-release surface.Journal of Drug Delivery Science and Technology, 2025, 105

2.Minxing Hu, Jianwei Bao, Yuanmei Zhang, Lele Wang, Ya Zhang, Jiaxin Zhang, Jihui Tang*, Qianli Zou*.Supramolecular Nanoparticles of Histone and Hyaluronic Acid for Co-Delivery of siRNA and Photosensitizer In Vitro.International Journal Of Molecular Sciences.2024,25(10):5424.

3.Yuji Xin, Yixuan Zou, Hanfang Lei, Yong Bi, Rui Yang, Jihui Tang*, Qingri Jin*.

Advances in Cyclodextrins and Their Derivatives in Nano-Delivery Systems.Pharmaceutics. 2024,16(8):1054.

4.Yawen Gao, Lele Wang, Xue Zhang, Ziling Zhou, Xinzhu Shen, Haodong Hu, Rui Sun, Jihui Tang*. Advances in Self-Assembled Peptides as Drug Carriers.Pharmaceutics.2023，15(2):482.

5.Jianwei Bao, Minxing Hu, Yuanmei Zhang, Qianqian Zhang, Feiyan Zhu, Qianli Zou*,Jihui Tang*. Novel active stealth micelles based on β2M achieved effective antitumor therapy.Biomedicine & Pharmacotherapy. 2022，151，113175.

6.Qianqian Zhang, Jianwei Bao, Tijie Duan, Minxing Hu, Yuting He, Junwei Wang, Rongfeng Hu*,Jihui Tang*. Nanomicelle-Microsphere Composite as a Drug Carrier to Improve Lung-Targeting Specificity for Lung Cancer,Pharmaceutics, 2022, 14(3): 510

7.Bo Li, Tingfei Tan, Weiwei Chu, Ying Zhang, Yuanzi Ye, Shanshan Wang, Yan Qin,Jihui Tang*, Xi Cao*. Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy.Drug Delivery, 2022, 29 (1):75-78.

8.Jianwei Bao, Qianqian Zhang, Tijie Duan,Rongfeng Hu,Jihui Tang*. The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery.Curr Drug Targets, 2021,22(8):922-946

9.Siyu Guan, Qianqian Zhang, Jianwei Bao, Tijie Duan, Rongfeng Hu, Tori Czech,Jihui Tang*.Phosphatidylserine targeting peptide-functionalized pH sensitive mixed micelles for enhanced anti-tumor drug delivery.European Journal of Pharmaceutics and Biopharmaceutics. 2020,147:87-101.

10.Siyu Guan, Qianqian Zhang, Jianwei Bao, Rongfeng Hu, Tori Czech,Jihui Tang *.Recognition Sites for Cancer-targeting Drug Delivery Systems.Current Drug Metabolism. 2019;20(10):815-834.

11.Jihui Tang*, Jie Ning, Xiaoyan Liu, Baoming Wu, Rongfeng Hu*. A Novel Amino Acid Sequence-based Computational Approach to Predicting Cell-penetrating Peptides.Current computer-aided drug design. 2019,15(3):206-211.

12.Wenxiu Hong, Rongfeng Hu, Xuechao Huang, Xiaoqian Lu, Tori Czech,Jihui Tang*. In vivo pharmacokinetics and biodistribution of novel all-trans retinoic acid derivative-loaded, folate-modified poly (L-amino acid) micelles.Journal of Drug Delivery Science & Technology. 2017, 41: 436-43.

13.Jihui Tang, Ziwei Liu, Fenqi Ji, Yao Li, Junjie Liu, Jian Song, Jun Li*, Jianping Zhou*. The role of the cell cycle in the cellular uptake of folate-modified poly (L-amino acid) micelles in a cell population.Nanoscale. 2015, 7(48): 20397-404.

14.Jihui Tang*, Xinqun Wang, Ting Wang, Feihu Chen, Jianping Zhou. In vivo pharmacokinetics, biodistribution and antitumor effect of amphiphilic poly(L-amino acids) micelles loaded with a novel all-trans retinoic acid derivative.European Journal of Pharmaceutical Sciences, 2014, 51(1): 157-64.

发表专利情况：

1）汤继辉;邹千里;鲍健威;一种免疫逃逸纳米制剂、制备方法及应用, 2021-12-13,中国, ZL 20211 1522727.2

2)汤继辉，韩治敏，何佳琪，柳圆圆，郑层层.一种紫杉醇粉雾剂的制备方法，中国专利：ZL201810603428.3（授权）

3)汤继辉，李俊，刘紫薇，宋见，纪玢琪，李瑶，刘俊节.一种肿瘤靶向聚合物胶束及其制备方法，2017.10.27，中国：ZL201510475783.3（授权）