袁斌，校聘教授，博士生导师，东南博士后合作导师

在世预赛免费直播入口、北京生物工程研究所、德克萨斯大学圣安东尼奥健康科学中心获得学士、硕士和博士学位，曾任乔治华盛顿大学医学院研究助理教授。课题组借助肿瘤分子药理学研究手段，结合体外细胞、体内动物模型和临床样本，重点关注肿瘤及其微环境中关键分子调控肿瘤发生、发展的分子机制，以及借助人工智能驱动的深度学习模型筛选抗肿瘤药物靶点、发现与设计抗肿瘤活性小分子化合物。在STTT（2024）、J Clin Invest（2014）、Science Advances（2019）、Journal for ImmunoTherapy of Cancer（2021）、Advanced Healthcare Materials（2024）、IJBS（2021）等SCI期刊上发表研究论文。获得国家优秀自费留学生奖学金，入选安徽省高层次创新创业引才项目和百人计划。

研究方向：肿瘤分子药理学

电子邮箱：yuanb_ahmu@163.com

办公室：基础楼418

部分代表性论文：

1. Yanni Lin#; Ling Li#;Bin Yuan#; Fei Luo#; Xiujuan Zhang#; Yuanjun Yang; Shaliu Luo; Jing Lin; Tianxing Ye; Youzhi Zhang; Shan Gao; Qinong Ye; Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1, Signal Transduct Target Ther. 2024, 9(1):337.

2. Saisai Ge#; Xinyue Wang#; Xinru Zhao; Lingling Yuan; Xuewei Bao; Caidie Sun; Zehua Gong; Jun Guo; Siyu Yuan; Danyou Hu; Jing Yang*;Bin Yuan*; Guiyang Zhang*; Responsive Multi-Arm PEG-Modified COF Nanocomposites: Dynamic Photothermal, pH/ROS Dual-Responsive, Targeted Carriers for Rheumatoid Arthritis Treatment, Adv Healthc Mater, 2024, e2401744.

3. Jing Yang; Leilei Qi; Huai-Chin Chiang; Bin Yuan*; Rong Li; Yanfen Hu*; BRCA1 Antibodies Matter, Int J Biol Sci. 2021, 17(12):3239-3254.

4.Bin Yuan; Curtis A Clark; Bogang Wu; Jing Yang; Justin M Drerup; Tianbao Li; Victor X Jin; Yanfen Hu; Tyler J Curiel*; Rong Li*; Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and anti-tumor immunity through a phosphotyrosine switch, J Immunother Cancer, 2021, 9: e001932.

5. Long Cheng#;Bin Yuan#; Sunyang Ying#; Chang Niu#; Hongxu Mai; Xin Guan; Xiaohui Yang; Yan Teng; Jing Lin; Junjian Huang; RuiJin; Jun Wu; Bo Liu; Shaohong Chang; Enqun Wang; Chunxia Zhang; Ning Hou; Xuan Cheng; Danyang Xu; Xiao Yang*; Shan Gao*; Qinong Ye*; PES1 is a critical component of telomerase assembly and regulates cellular senescence, Sci Adv, 2019, 5(5): eaav1090.

6.Bin Yuan#; Long Cheng#; Huai-Chin Chiang; Xiaojie Xu; Yongjian Han; Hang Su; Lingxue Wang; Bo Zhang; Jing Lin; Xiaobing Li; XiangyangXie; Tao Wang; Rajeshwar R Tekmal; Tyler J Curiel; Zhi-Min Yuan; Richard Elledge; Yanfen Hu; Qinong Ye*; Rong Li*; A phosphotyrosine switch determines the antitumor activity of ERb, J Clin Invest, 2014, 124(8): 3378-3390.